Article
Genetic inhibitors of APOBEC3B-induced mutagenesis.
Genome research - 1 Sept 2023
Mertz Tony M, Rice-Reynolds Elizabeth, Nguyen Ly, Wood Anna, Cordero Cameron, Bray Nicholas, Harcy Victoria, Vyas Rudri K, Mitchell Debra, Lobachev Kirill, Roberts Steven A
Abstract excerpt
The cytidine deaminases APOBEC3A (A3A) and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we used a screen to identify 61 gene deletions that increase A3B-induced mutations in yeast. We also determined whether each deletion was epistatic with Ung1 loss, which indicated whether the encoded factors...
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