Article

Explainable Machine Learning Identifies Factors for Dosage Compensation in Aneuploid Human Cancer Cells

2025-05-13

Abstract excerpt

Aneuploidy, a hallmark of cancer, leads to widespread changes in chromosome copy number, altering the abundance of hundreds or thousands of proteins. How-ever, evidence suggests that levels of proteins encoded on affected chromosomes are often buffered toward their abundances observed in diploid cells. Despite its preval-ence, the molecular mechanisms driving this protein dosage compensation remain largely unknown...

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Literature Corpus work: 694391d1-d551-5221-9969-f6c228054efa
DOI: 10.1101/2025.05.12.653427

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