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Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

16 May 2022

Abstract excerpt

Aneuploidy, a state of chromosome imbalance, is a hallmark of human tumors, but its role in cancer still remains to be fully elucidated. To understand the consequences of whole-chromosome-level aneuploidies on the proteome, we integrated aneuploidy, transcriptomic, and proteomic data from hundreds of The Cancer Genome Atlas/Clinical Proteomic Tumor Analysis Consortium tumor samples. We found a surprisingly large...

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PMID: 35575458
DOI: 10.7554/elife.75526

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