Article

Extensive protein dosage compensation in aneuploid human cancers

2021-06-18

Abstract excerpt

Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein expression remain poorly understood. To uncover how chromosome copy number changes influence the cancer proteome, we have conducted an analysis of hundreds of human cancer cell lines with matched copy number, RNA expression, and protein expression data. We found that a majority of proteins exhibit dosage compensation and fail to ch...

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Literature Corpus work: 0b60b37a-fb29-56e9-95d9-35fd215111ba
DOI: 10.1101/2021.06.18.449005

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