Article

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

2023-12-19

Abstract excerpt

Chromosomal gains are among the most frequent somatic genetic alterations occurring in cancer. While the effect of sustained oncogene expression has been characterized, the impact of copy-number gains affecting collaterally-amplified “bystander” genes on cellular fitness remains less understood. To investigate this, we built a comprehensive map of dosage compensations across human cancers by integrating expression...

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Literature Corpus work: 63c16877-e1f8-54d4-9516-fd803930e6e1
DOI: 10.1101/2023.12.16.571980

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