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Article

Gene dosage imbalances: action, reaction, and models.

Trends in biochemical sciences - 1 Jun 2015

Veitia Reiner A, Potier Marie Claude

Abstract excerpt

Single-gene deletions, duplications, and misregulation, as well as aneuploidy, can lead to stoichiometric imbalances within macromolecular complexes and cellular networks, causing their malfunction. Such alterations can be responsible for inherited or somatic genetic disorders including Mendelian diseases, aneuploid syndromes, and cancer. We review the effects of gene dosage alterations at the transcriptomic and...

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Identifiers

PMID: 25937627
DOI: 10.1016/j.tibs.2015.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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