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Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers

1 Jul 2021

Abstract excerpt

Uncoupling of mRNA expression from copy number (UECN) might be a strategy for cancer cells to a tolerate high degree of aneuploidy. To test the extent and role of UECN across cancers, we perform integrative multiomic analysis of The Cancer Genome Atlas (TCGA) dataset, encompassing ∼5,000 individual tumors. We find UECN is common in cancers and is associated with increased oncogenic signaling, proliferation, and...

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PMID: 34337565
DOI: 10.1016/j.xcrm.2021.100349

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