Article

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

2023-05-06

Abstract excerpt

Aneuploidy and resulting gene copy number alterations (CNAs) are important hallmarks of human cancers. Since CNAs are not associated with dosage compensation in mRNA expression, cancer cells with a high CNA burden must harbor mechanisms to mitigate proteotoxic stress resulting from stoichiometric imbalance and accumulation of unfolded proteins ( 1 ). Here, we show that aneuploid human cancer cells exhibit discord...

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Literature Corpus work: 2b931a6b-7cee-5808-93bf-609f5bf09841
DOI: 10.1101/2023.05.04.539299

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