Article

Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

2021-12-09

Abstract excerpt

Aneuploidy, a state of chromosome imbalance, is a hallmark of human tumors, but its role in cancer still remains to be fully elucidated. To understand the consequences of whole chromosome-level aneuploidies on the proteome, we integrated aneuploidy, transcriptomic and proteomic data from hundreds of TCGA/CPTAC tumor samples. We found a surprisingly large number of expression changes happened on other, non-aneuploi...

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Literature Corpus work: f8e79ae6-9a4d-5740-9d8b-c3b968d54a36
DOI: 10.1101/2021.12.05.471308

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