Article

<i>MYC</i> dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

2021-04-23

Abstract excerpt

<h4>Summary</h4> We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multi-omics data and developed a biocomputational platform to construct a mathematical model of their interaction network with miRNAs and transcription factors, where the property of dosage...

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Literature Corpus work: 218f96ed-7b97-5641-bd27-f3be1a3f2029
DOI: 10.1101/2021.04.20.440572

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