Article

Proteogenomic analysis of aneuploidy reveals divergent types of gene expression regulation across cellular pathways

2021-12-09

Abstract excerpt

How cells control gene expression is a fundamental question. The relative contribution of protein-level and transcript-level regulation to this process remains unclear. Here we perform a proteogenomic analysis of tumors and untransformed cells containing somatic copy number alterations (SCNAs). By revealing how cells regulate transcript and protein abundances of SCNA-containing genes, we provide insights into the...

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Literature Corpus work: 54fb3729-1e2f-5284-8ca6-876a9eb46a79
DOI: 10.1101/2021.12.07.471176

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