Article

3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk Genes

2022-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified over 100 loci associated with osteoarthrtis (OA) risk, but the majority of OA risk variants are non-coding, making it difficult to identify the impacted genes for further study and therapeutic development. To address this need, we used a multi-omic approach and genome editing to identify and functionally characterize potential OA risk genes....

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Literature Corpus work: 6920bb82-72b4-5f2c-a060-c1b75155f11c
DOI: 10.1101/2022.05.16.492146

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