Article

Leveraging single cell multiomic analyses to identify factors that drive human chondrocyte cell fate

2024-06-12

Abstract excerpt

Cartilage plays a crucial role in skeletal development and function, and abnormal development contributes to genetic and age-related skeletal disease. To better understand how human cartilage develops in vivo , we jointly profiled the transcriptome and open chromatin regions in individual nuclei recovered from distal femurs at 2 fetal timepoints. We used these multiomic data to identify transcription factors expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26137d6f-3f82-503a-87c2-fe2f97232657
DOI: 10.1101/2024.06.12.598666

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging single cell multiomic analyses to identify factors that drive human chondrocyte cell fateDOI 10.1101/2024.06.12.598666Read

A multiomic atlas of human early skeletal developmentSemantic proximity Read

Lineage-specific differences and regulatory networks governing human chondrocyte developmentSemantic proximity Read

Lineage-Specific Differences and Regulatory Networks Governing Human Chondrocyte DevelopmentSemantic proximity Read

Integrated mapping of human meniscus and cartilage eQTLs reveals shared and distinct osteoarthritis genetic driversSemantic proximity Read

Chromatin and gene-regulatory dynamics of human pulmogenesis by single cell multiomic sequencingSemantic proximity Read

Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritisSemantic proximity Read

A single-cell atlas of chromatin accessibility in the human genome.Semantic proximity Read

Nuclear Factor I genes drive chondrogenic cell-fate commitmentSemantic proximity Read

Comprehensive profiling of transcriptional regulation in cartilage reveals pathogenesis of osteoarthritisSemantic proximity Read

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytesSemantic proximity Read

A cell atlas of chromatin accessibility across 25 adult human tissuesSemantic proximity Read

3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk GenesSemantic proximity Read