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3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes

13 Sept 2022

Abstract excerpt

Genome-wide association studies have identified over 100 loci associated with osteoarthritis risk, but the majority of osteoarthritis risk variants are noncoding, making it difficult to identify the impacted genes for further study and therapeutic development. To address this need, we used a multiomic approach and genome editing to identify and functionally characterize potential osteoarthritis risk genes....

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PMID: 36099032
DOI: 10.1093/genetics/iyac141

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