Article
Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk.
Cell genomics - 8 Jan 2025
Kramer Nicole E, Byun Seyoun, Coryell Philip, D'Costa Susan, Thulson Eliza, Kim HyunAh, Parkus Sylvie M, Bond Marielle L, Klein Emma R, Shine Jacqueline, Chubinskaya Susanna, Love Michael I, Mohlke Karen L, Diekman Brian O, Loeser Richard F, Phanstiel Douglas H
Abstract excerpt
Osteoarthritis (OA) poses a significant healthcare burden with limited treatment options. While genome-wide association studies (GWASs) have identified over 100 OA-associated loci, translating these findings into therapeutic targets remains challenging. To address this gap, we mapped gene expression, chromatin accessibility, and 3D chromatin structure in primary human articular chondrocytes in both resting and...
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