Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes

Abstract excerpt

Objectives Osteoarthritis is a complex disease with a huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organisation in three-dimensional (3D) space is essential for identifying long-range contacts between distant genomic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Chromatin Dynamics
• Share to Osteoarthritis Treatment and Mechanisms
• Share to Rheumatoid Arthritis Research and Therapies