Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease.

Current rheumatology reports - 1 Jun 2024

Roberts Jack B, Rice Sarah J

Abstract excerpt

PURPOSE OF REVIEW: Osteoarthritis is a complex and highly polygenic disease. Over 100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly conferring functional effects through the disruption of regulatory elements impacting target gene expression. In this review, we summarise the progress that has advanced our knowledge of gene enhancers both within the field of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cytokine Signaling Pathways and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Osteoarthritis

Share to Osteoarthritis Treatment and Mechanisms

Source

Open in PubMed Open full text

Identifiers

PMID: 38430365
DOI: 10.1007/s11926-024-01142-z
PMCID: PMC11116181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease.PMID 38430365Read ↗

Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.Semantic proximity Read ↗

Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genesSemantic proximity Read ↗

Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisSemantic proximity Read ↗

Comprehensive profiling of transcriptional regulation in cartilage reveals pathogenesis of osteoarthritisSemantic proximity Read ↗

Genetics of osteoarthritis.Semantic proximity Read ↗

Genome-wide analysis of aberrant methylation of enhancer DNA in human osteoarthritisSemantic proximity Read ↗

The Genetics and Functional Genomics of Osteoarthritis.Semantic proximity Read ↗

Chromatin accessibility landscape of articular knee cartilage reveals aberrant enhancer regulation in osteoarthritisSemantic proximity Read ↗

Chromatin accessibility landscape of articular knee cartilage reveals aberrant enhancer regulation in osteoarthritisSemantic proximity Read ↗

A molecular quantitative trait locus map for osteoarthritis.Semantic proximity Read ↗

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis riskSemantic proximity Read ↗

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.