Article

Comprehensive profiling of transcriptional regulation in cartilage reveals pathogenesis of osteoarthritis

2024-06-12

Abstract excerpt

Cartilage damage is a leading cause of osteoarthritis (OA) etiology, however, the underlying mechanism governing gene expression regulation in this progress is poorly understood. Here, we described a comprehensive profiling of transcriptional regulation of 235 primary human cartilage samples. We identified 3,352 independent significant expression quantitative trait loci (eQTLs) for 3,109 genes. We explored the can...

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Literature Corpus work: a1f86c1e-625d-5fa1-adde-abc295b8f301
DOI: 10.1101/2024.06.11.598401

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