Article

Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes

2024-11-12

Abstract excerpt

Osteoarthritis affects millions worldwide, yet effective treatments remain elusive due to poorly understood molecular mechanisms. While genome-wide association studies (GWAS) have identified over 100 OA-associated loci, identifying the genes impacted at each locus remains challenging. Several studies have mapped expression quantitative trait loci (eQTL) in chondrocytes and colocalized them with OA GWAS variants to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b679769-9614-5262-a9b0-15925c67b626
DOI: 10.1101/2024.11.11.622754

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genesDOI 10.1101/2024.11.11.622754Read

3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk GenesSemantic proximity Read

Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.Semantic proximity Read

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genesSemantic proximity Read

Genetic alternative splicing regulation mapping of cartilage and synovium reveals tissue-specific mechanisms of joint-related traits.Semantic proximity Read

Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genesSemantic proximity Read

Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisSemantic proximity Read

Integrated mapping of human meniscus and cartilage eQTLs reveals shared and distinct osteoarthritis genetic driversSemantic proximity Read

Comprehensive profiling of transcriptional regulation in cartilage reveals pathogenesis of osteoarthritisSemantic proximity Read

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis riskSemantic proximity Read

A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritisSemantic proximity Read

Functional Testing of Thousands of Osteoarthritis-Associated Variants for Regulatory ActivitySemantic proximity Read

A molecular quantitative trait locus map for osteoarthritis.Semantic proximity Read