Article
A molecular quantitative trait locus map for osteoarthritis.
Nature communications - 26 Feb 2021
Steinberg Julia, Southam Lorraine, Roumeliotis Theodoros I, Clark Matthew J, Jayasuriya Raveen L, Swift Diane, Shah Karan M, Butterfield Natalie C, Brooks Roger A, McCaskie Andrew W, Bassett J H Duncan, Williams Graham R, Choudhary Jyoti S, Wilkinson J Mark, Zeggini Eleftheria
Abstract excerpt
Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synovium from 115 patients with osteoarthritis to construct a deep molecular signature map of the disease. By integrating...
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