Article

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

2022-10-25

Abstract excerpt

Coronary artery disease (CAD) and atherosclerosis are characterized by plaque formation in the arteries wall. CAD progression involves complex interactions and phenotypic plasticity within and between distinct vascular and immune cell lineages. Single-cell RNA-seq (scRNA-seq) studies have highlighted lineage-specific transcriptomic signatures, but the reported cell phenotypes in humans remain controversial. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c205b7c2-5458-58b8-ab8c-3875ba120b39
DOI: 10.1101/2022.10.24.513520

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosisDOI 10.1101/2022.10.24.513520Read

Integrated single-cell atlas of human atherosclerotic plaquesSemantic proximity Read

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read

Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease riskSemantic proximity Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.Semantic proximity Read

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosisSemantic proximity Read

Decoding the transcriptome of atherosclerotic plaque at single-cell resolutionSemantic proximity Read

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures.Semantic proximity Read

Unveiling the Hidden Landscape of Arterial Diseases at Single-Cell Resolution.Semantic proximity Read