Article
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells.
Circulation research - 4 Dec 2020
Aherrahrou Redouane, Guo Liang, Nagraj V Peter, Aguhob Aaron, Hinkle Jameson, Chen Lisa, Yuhl Soh Joon, Lue Dillon, Alencar Gabriel F, Boltjes Arjan, van der Laan Sander W, Farber Emily, Fuller Daniela, Anane-Wae Rita, Akingbesote Ngozi, Manichaikul Ani W, Ma Lijiang, Kaikkonen Minna U, Björkegren Johan L M, Önengüt-Gümüşcü Suna, Pasterkamp Gerard, Miller Clint L, Owens Gary K, Finn Aloke, Navab Mohamad, Fogelman Alan M, Berliner Judith A, Civelek Mete
Abstract excerpt
RATIONALE: Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Recent genome-wide association studies revealed 163 loci associated with CAD. However, the precise molecular mechanisms by which the majority of these loci increase CAD risk are not known. Vascular smooth muscle cells (VSMCs) are critical in the development of CAD. They can play either beneficial or detrimental roles...
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