Article

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis

2024-10-06

Abstract excerpt

<h4>Background</h4> Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the western world despite the success of lipid lowering therapies, highlighting the need for novel lipid-independent therapeutic strategies. Genome-wide association studies (GWAS) have identified numerous genes associated with ASCVD that function in the vessel wall, suggesting that vascular cells mediate A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e84bf99-13c6-58b7-ae6f-1e4e98e82111
DOI: 10.1101/2024.10.05.616802

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse AtherosclerosisDOI 10.1101/2024.10.05.616802Read

Integrated single-cell RNA-seq analysis reveals the vital cell types and dynamic development signature of atherosclerosisSemantic proximity Read

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read

Desert hedgehog enhances endothelial resilience and prevents atherosclerosis by mitigating PAI-1 signalingSemantic proximity Read

Single-Cell Multimodal Profiling Reveals a Novel CD26 <sup>+</sup> Fibroblast Subpopulation in AtherosclerosisSemantic proximity Read

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic ModulationSemantic proximity Read

Immune interaction signatures in adipose tissue fibroblasts in obesity-associated atherosclerosisSemantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosisSemantic proximity Read

Single-Cell Multimodal Profiling Reveals a Novel CD26+ Fibroblast Subpopulation in Atherosclerosis-Brief Report.Semantic proximity Read

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.Semantic proximity Read

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending AortopathiesSemantic proximity Read

Identification of cellular heterogeneity and key signaling pathways associated with vascular remodeling and calcification in young and old primate aortas based on single-cell analysisSemantic proximity Read