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Article

Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2022

Belsare Ketaki D, Wu Haifan, Mondal Dibyendu, Bond Annalise, Castillo Erika, Jin Jia, Jo Hyunil, Roush Addison E, Pilla Kala Bharath, Sali Andrej, Condello Carlo, DeGrado William F

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form. Mutations in TREM2 have been linked to increased risk of Alzheimer's disease (AD). A prominent neuropathological component of AD is deposition of the amyloid-β (Aβ) into plaques, particularly Aβ40 and Aβ42. While the membrane-bound form of...

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Identifiers

PMID: 35082148
DOI: 10.1073/pnas.2114486119
PMCID: PMC8812518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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