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The role of TREM2 in Alzheimer’s disease: from the perspective of Tau

8 Nov 2023

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for Alzheimer's disease (AD). Several studies have already demonstrated the relationship between TREM2 and Tau. TREM2 mutations and altered expression play an important role in Tau phosphorylation. Furthermore, the level of Tau phosphorylation...

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PMID: 38020891
DOI: 10.3389/fcell.2023.1280257

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