Article
H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Cancer cell - 13 Nov 2017
Pathania Manav, De Jay Nicolas, Maestro Nicola, Harutyunyan Ashot S, Nitarska Justyna, Pahlavan Pirasteh, Henderson Stephen, Mikael Leonie G, Richard-Londt Angela, Zhang Ying, Costa Joana R, Hébert Steven, Khazaei Sima, Ibrahim Nisreen Samir, Herrero Javier, Riccio Antonella, Albrecht Steffen, Ketteler Robin, Brandner Sebastian, Kleinman Claudia L, Jabado Nada, Salomoni Paolo
Abstract excerpt
Gain-of-function mutations in histone 3 (H3) variants are found in a substantial proportion of pediatric high-grade gliomas (pHGG), often in association with TP53 loss and platelet-derived growth factor receptor alpha (PDGFRA) amplification. Here, we describe a somatic mouse model wherein H3.3K27M and Trp53 loss alone are sufficient for neoplastic transformation if introduced in utero. H3.3K27M-driven lesions are...
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