Article

Cooperativity between H3.3K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatars

2023-02-24

Abstract excerpt

Diffuse midline glioma (DMG) is a leading cause of brain tumor death in children. In addition to hallmark H3.3K27M mutations, significant subsets also harbor alterations of other genes, such as TP53 and PDGFRA . Despite the prevalence of H3.3K27M, the results of clinical trials in DMG have been mixed, possibly due to the lack of models recapitulating its genetic heterogeneity. To address this gap, we developed h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d407b64f-6d70-52c7-bf0b-47f489002152
DOI: 10.1101/2023.02.24.528982

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cooperativity between H3.3K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatarsDOI 10.1101/2023.02.24.528982Read

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.Semantic proximity Read

A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell-of-origin dependent effects of H3K27M.Semantic proximity Read

H3G34-Mutant Gliomas—A Review of Molecular Pathogenesis and Therapeutic OptionsSemantic proximity Read

New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of H3K27M-Mutant Diffuse Midline GliomaSemantic proximity Read

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.Semantic proximity Read

Oncohistone inhibition reshapes tumor–microenvironment communication in Diffuse Midline Glioma (DMG)Semantic proximity Read

H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions.Semantic proximity Read

A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4.Semantic proximity Read

NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas.Semantic proximity Read

Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations.Semantic proximity Read

Identification of prognostic markers in diffuse midline gliomas H3K27M-mutant.Semantic proximity Read

Survival analysis of adult midline-located gliomas and diffuse midline gliomas: beyond the H3K27 mutation paradigm.Semantic proximity Read