Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.

doi:10.1093/nar/gkad1257

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Article

Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.

Nucleic acids research - 21 Mar 2024

Giacomini Giulia, Piquet Sandra, Chevallier Odile, Dabin Juliette, Bai Siau-Kun, Kim Byungjin, Siddaway Robert, Raught Brian, Coyaud Etienne, Shan Chun-Min, Reid Robert J D, Toda Takenori, Rothstein Rodney, Barra Viviana, Wilhelm Therese, Hamadat Sabah, Bertin Chloé, Crane Alexander, Dubois Frank, Forne Ignasi, Imhof Axel, Bandopadhayay Pratiti, Beroukhim Rameen, Naim Valeria, Jia Songtao, Hawkins Cynthia, Rondinelli Beatrice, Polo Sophie E

Abstract excerpt

Pediatric high-grade gliomas (pHGG) are devastating and incurable brain tumors with recurrent mutations in histone H3.3. These mutations promote oncogenesis by dysregulating gene expression through alterations of histone modifications. We identify aberrant DNA repair as an independent mechanism, which fosters genome instability in H3.3 mutant pHGG, and opens new therapeutic options. The two most frequent H3.3...

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PMID: 38214234
DOI: 10.1093/nar/gkad1257
PMCID: PMC10954481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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