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The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis.

Current biology : CB - 20 Jan 2025

Day Charles A, Grigore Florina, Hakkim Faruck L, Paul Souren, Langfald Alyssa, Weberg Molly, Fadness Sela, Schwab Paiton, Sepaniac Leslie, Stumpff Jason, Vaughan Kevin T, Daniels David J, Robinson James P, Hinchcliffe Edward H

Abstract excerpt

Serine 31 is a phospho-site unique to the histone H3.3 variant; mitotic phospho-Ser31 is restricted to pericentromeric heterochromatin, and disruption of phospho-Ser31 results in chromosome segregation defects and loss of p53-dependant G1 cell-cycle arrest.1,2,3,4 Ser31 is proximal to the H3.3 lysine 27-to-methionine (K27M) mutation that drives ∼80% of pediatric diffuse midline gliomas.5,6,7,8,9,10,11,12 Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39729988
DOI: 10.1016/j.cub.2024.11.035
PMCID: PMC12673919

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