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Article

Evolutionary dynamics in the decades preceding acute myeloid leukaemia

2024-07-10

Abstract excerpt

Somatic evolution in ageing tissues underlies many cancers. However, our quantitive understanding of the rules governing this pre-cancerous evolution remains incomplete. Here we exploit a unique collection of serial blood samples collected annually up to 15 years prior to diagnosis of acute myeloid leukaemia (AML) to provide a quantitative description of pre-cancerous evolutionary dynamics. Using deep duplex seque...

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Identifiers and source

Literature Corpus work
82f5efcc-89d2-561d-8a06-e5268f1c4128
DOI
10.1101/2024.07.05.602251
Open publication

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Evolutionary dynamics in the decades preceding acute myeloid leukaemiaDOI 10.1101/2024.07.05.602251
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