Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age distinguishes selection from causation in cancer genomes.

Nature genetics - 1 Jun 2026

Cheek David, Blohmer Martin, Nowak Martin A, Antal Tibor, Naxerova Kamila

Abstract excerpt

Cancer-causing mutations have been identified primarily from positive selection signals in cancer genomes. However, positive selection is also a ubiquitous feature of normal tissue aging. Here we develop a statistical framework to disentangle selection in normal tissue and causation of carcinogenesis. By comparing cancer and normal tissue genomes, we estimate the effects of mutations on cancer risk in the blood,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aging
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Leukemia, Myeloid, Acute

Share to Models, Genetic

Share to Neoplasms

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42086853
DOI: 10.1038/s41588-026-02593-z
PMCID: PMC13263150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age distinguishes selection from causation in cancer genomes.PMID 42086853Read ↗

Age distinguishes selection from causation in cancer genomesSemantic proximity Read ↗

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging bloodSemantic proximity Read ↗

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood.Semantic proximity Read ↗

Universal patterns of selection in cancer and somatic tissuesSemantic proximity Read ↗

Universal Patterns of Selection in Cancer and Somatic Tissues.Semantic proximity Read ↗

Cells with cancer‐associated mutations overtake our tissues as we ageSemantic proximity Read ↗

Mutations, substitutions, and selection: Linking mutagenic processes to cancer using evolutionary theory.Semantic proximity Read ↗

Bayesian inference of negative and positive selection in human cancers.Semantic proximity Read ↗

Accumulation of Oncogenic Mutations During Progression from Healthy Tissue to Cancer.Semantic proximity Read ↗

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.Semantic proximity Read ↗

Computationally reconstructing the evolution of cancer progression riskSemantic proximity Read ↗

The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging-related disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.