Article

Age distinguishes selection from causation in cancer genomes

2025-10-06

Abstract excerpt

Cancer genome sequencing efforts have revealed hundreds of genes under positive selection, many of which are now being developed as therapeutic targets. However, positively selected mutations also populate our aging tissues in the absence of cancer. For most mutations, it is currently unknown whether they are recurrently found in cancer genomes because they cause cancer or because they expand during normal tissue...

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Literature Corpus work: e98d8d0b-ef48-5a2d-90c3-ab84627fc92e
DOI: 10.1101/2025.10.06.680730

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