Article

HLA Alleles Imprint Distinct Biases in the Usage Preferences of TCR Vβ segments

2026-02-20

Abstract excerpt

T cells must co-recognize peptide and HLA, yet the extent to which this specificity is shaped by germline-encoded TCR–HLA contacts versus selection during thymic development has remained difficult to quantify. Leveraging population-scale TCR β repertoires linked to donor HLA genotypes, we construct allele-specific V β usage profiles and normalize them to repertoire-wide baselines to derive interpretable HLA-TCR...

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Literature Corpus work: 6830743b-50b1-5708-95a5-ffc40449a420
DOI: 10.64898/2026.02.19.706729

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