HLA alleles shape distinct biases in the usage preferences of TCR Vβ segments.

Abstract excerpt

T cells must co-recognize peptide and HLA, yet the extent to which this specificity is shaped by germline-driven TCR-HLA contacts has remained difficult to quantify. Leveraging population-scale TCRβ repertoires linked to donor HLA genotypes inferred using validated imputation models, we construct allele-specific TCR Vβ gene usage profiles and normalize them to repertoire-wide baselines to derive interpretable...

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