Article
Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.
PloS one - 1 Jan 2015
Klarenbeek Paul L, Doorenspleet Marieke E, Esveldt Rebecca E E, van Schaik Barbera D C, Lardy Neubury, van Kampen Antoine H C, Tak Paul P, Plenge Robert M, Baas Frank, de Bakker Paul I W, de Vries Niek
Abstract excerpt
Every person carries a vast repertoire of CD4+ T-helper cells and CD8+ cytotoxic T cells for a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell receptor (TCR) is a key step during T-cell development, but how a single T cell commits to become either CD4+ or CD8+ is poorly understood. To evaluate the influence of TCR sequence variation on CD4+/CD8+ lineage commitment, we...
Topics
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Lineage
- Genes, T-Cell Receptor
- Genes, T-Cell Receptor alpha
- Genes, T-Cell Receptor beta
- Genetic Variation
- HLA Antigens
- Humans
- Receptors, Antigen, T-Cell