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Article

Genetic variation in MHC proteins is associated with T cell receptor expression biases.

Nature genetics - 1 Sept 2016

Sharon Eilon, Sibener Leah V, Battle Alexis, Fraser Hunter B, Garcia K Christopher, Pritchard Jonathan K

Abstract excerpt

In each individual, a highly diverse T cell receptor (TCR) repertoire interacts with peptides presented by major histocompatibility complex (MHC) molecules. Despite extensive research, it remains controversial whether germline-encoded TCR-MHC contacts promote TCR-MHC specificity and, if so, whether differences exist in TCR V gene compatibilities with different MHC alleles. We applied expression quantitative trait...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27479906
DOI: 10.1038/ng.3625
PMCID: PMC5010864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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