Article

HLA Type and Chronic Viral Infection Impact Peripheral T-cell Receptor Sharing Between Unrelated Individuals

2021-03-20

Abstract excerpt

<h4>ABSTRACT</h4> The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random process that results in repertoires that are largely private to each individual. However, certain factors such as low junctional diversity, thymic select...

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Literature Corpus work: 9152c5f1-5415-59c9-b662-b1611a82209a
DOI: 10.1101/2021.03.19.436220

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