Article

Divergent effects of pathological α-synuclein truncations and mutations on phase separation

2024-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Phase separated condensates can accelerate α-synuclein (α-Syn) amyloid fibril formation implicated in Parkinson’s disease pathogenesis. The effects of pathological modifications, i.e., truncations and familial mutations on the thermodynamics, material properties, and the extent of amyloid aggregation within α-Syn condensates remain elusive. Here, we quantitatively demonstrate that terminal trunc...

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Literature Corpus work: fcdc59c0-c3c8-539c-a900-862b23722303
DOI: 10.1101/2024.11.18.624073

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