Article

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

2020-03-05

Abstract excerpt

The aggregation of the intrinsically disordered tau protein into highly ordered β-sheet fibrils is implicated in many neurodegenerative disorders. Fibrillation mechanism remains unresolved, particularly early events that trigger tau misfolding and assembly. We investigated the role membrane plays in modulating aggregation of three tau variants, the largest isoform hTau40, the truncated construct K18, and a hyperph...

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Identifiers and source

Literature Corpus work: ebeee74f-e537-5f58-a72e-f3a4431c7cf9
DOI: 10.1101/2020.03.04.977421

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