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Article

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2020

Boyko Solomiia, Surewicz Krystyna, Surewicz Witold K

Abstract excerpt

One of the hallmarks of Alzheimer's disease and several other neurodegenerative disorders is the aggregation of tau protein into fibrillar structures. Building on recent reports that tau readily undergoes liquid-liquid phase separation (LLPS), here we explored the relationship between disease-related mutations, LLPS, and tau fibrillation. Our data demonstrate that, in contrast to previous suggestions, pathogenic...

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Identifiers

PMID: 33262278
DOI: 10.1073/pnas.2012460117
PMCID: PMC7749306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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