Article

Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis

2025-09-10

Abstract excerpt

Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (Pol η) is most recognised for tolerating UV-induced DNA damage via translesion synthesis (TLS). However, emerging evidence suggests a broader contribution of error-prone polymerases to DNA synthesis. To elucidate the r...

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Literature Corpus work: 67bdc640-7a89-5005-b123-cf033cde5002
DOI: 10.1101/2025.09.10.675280

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