Polymerase ι promotes C>T substitutions in smoking models and in the platinum chemotherapy-induced SBS31 mutation signature.

Abstract excerpt

DNA damage occasionally leads to mutations even in DNA repair-proficient cells via translesion synthesis (TLS), an efficient but error-prone DNA damage tolerance pathway. In the human genome, there are three closely related Y-family TLS polymerases (η, κ, and ι). Polymerase η is specialized for the error-free replication of UV adducts, while polymerase κ is known to replicate over various heterocyclic DNA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 4-Nitroquinoline-1-oxide
• Share to Antineoplastic Agents