Article

Activity of DNA polymerase κ across the genome in human fibroblasts

2024-02-23

Abstract excerpt

DNA polymerase κ (Pol κ) is a specialized polymerase that has multiple cellular roles such as translesion DNA synthesis, replicating repetitive sequences, and nucleotide excision repair. We have developed a method for capturing DNA synthesized by Pol κ utilizing a Pol κ - specific substrate, N 2 -(4-ethynylbenzyl)-2′-deoxyguanosine (EBndG). After shearing of the DNA into 200-500bp lengths, the EBndG-containing DN...

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Identifiers and source

Literature Corpus work: 9fdbe0ee-645d-5ae5-8359-4b2154f0ccc8
DOI: 10.1101/2024.02.22.581598

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