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Article

Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae.

DNA repair - 1 Nov 2015

Donigan Katherine A, Cerritelli Susana M, McDonald John P, Vaisman Alexandra, Crouch Robert J, Woodgate Roger

Abstract excerpt

DNA polymerase η (pol η) is best characterized for its ability to perform accurate and efficient translesion DNA synthesis (TLS) through cyclobutane pyrimidine dimers (CPDs). To ensure accurate bypass the polymerase is not only required to select the correct base, but also discriminate between NTPs and dNTPs. Most DNA polymerases have a conserved "steric gate" residue which functions to prevent incorporation of...

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Identifiers

PMID: 26340535
DOI: 10.1016/j.dnarep.2015.07.002
PMCID: PMC4651834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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