Article
DNA polymerase η mutational signatures are found in a variety of different types of cancer.
Cell cycle (Georgetown, Tex.) - 1 Jan 2018
Rogozin Igor B, Goncearenco Alexander, Lada Artem G, De Subhajyoti, Yurchenko Vyacheslav, Nudelman German, Panchenko Anna R, Cooper David N, Pavlov Youri I
Abstract excerpt
DNA polymerase (pol) η is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions of immunoglobulin genes. Misregulation and mistargeting of pol η can compromise genome integrity. We explored whether the mutational signature of pol η could be found...
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