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Article

Unravelling roles of error-prone DNA polymerases in shaping cancer genomes.

Oncogene - 1 Dec 2021

Vaziri Cyrus, Rogozin Igor B, Gu Qisheng, Wu Di, Day Tovah A

Abstract excerpt

Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse underlying mutagenic mechanisms that shape cancer genomes are not understood. This review will consider the emerging challenge of determining how DNA damage response pathways-both tolerance and repair-act upon specific forms of DNA damage to generate mutations characteristic of tumors. DNA polymerases are typically the...

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Identifiers

PMID: 34663880
DOI: 10.1038/s41388-021-02032-9
PMCID: PMC8639439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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