Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ.

Life science alliance - 1 Apr 2021

Yoon Jung-Hoon, Basu Debashree, Sellamuthu Karthi, Johnson Robert E, Prakash Satya, Prakash Louise

Abstract excerpt

By extending synthesis opposite from a diverse array of DNA lesions, DNA polymerase (Pol) ζ performs a crucial role in translesion synthesis (TLS). In yeast and cancer cells, Rev1 functions as an indispensable scaffolding component of Polζ and it imposes highly error-prone TLS upon Polζ. However, for TLS that occurs during replication in normal human cells, Rev1 functions instead as a scaffolding component of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to DNA Adducts
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase beta

Share to DNA Replication

Share to Gene Knockdown Techniques

Share to Pyrimidine Dimers

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 33514655
DOI: 10.26508/lsa.202000900
PMCID: PMC7898466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ.PMID 33514655Read ↗

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.Semantic proximity Read ↗

Translesion synthesis DNA polymerases and control of genome stability.Semantic proximity Read ↗

DNA polymerase λ promotes error-free replication through Watson-Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ.Semantic proximity Read ↗

Translesion DNA Synthesis and CarcinogenesisSemantic proximity Read ↗

DNA polymerase delta in dna replication and genome maintenanceSemantic proximity Read ↗

The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.Semantic proximity Read ↗

Translesion and Repair DNA Polymerases: Diverse Structure and MechanismSemantic proximity Read ↗

Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesisSemantic proximity Read ↗

Role of DNA polymerase κ in the maintenance of genomic stabilitySemantic proximity Read ↗

Polymerase Delta in Eukaryotes: How is It Transiently Exchanged with Specialized DNA Polymerases During Translesion DNA Synthesis?Semantic proximity Read ↗

Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA.Semantic proximity Read ↗

Error-prone repair DNA polymerases in prokaryotes and eukaryotes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.