Article

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

2017-10-29

Abstract excerpt

Nuclear shape and architecture influence gene localization, mechanotransduction, transcription, and cell function. Abnormal nuclear morphology and protrusions termed “blebs” are diagnostic markers for many human afflictions including heart disease, aging, progeria, and cancer. Nuclear blebs are associated with both lamin and chromatin alterations. A number of prior studies suggest that lamins dictate nuclear morph...

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Literature Corpus work: 3574615f-3404-5f98-a8a8-a7231f675f4f
DOI: 10.1101/206367

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