Article

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

2018-09-21

Abstract excerpt

The nucleus houses, organizes, and protects chromatin to ensure genome integrity and proper gene expression, but how the nucleus adapts mechanically to changes in the extracellular environment is poorly understood. Recent studies have revealed that extracellular chemical or physical stresses induce chromatin compaction via mechanotransductive processes. We report that increased extracellular multivalent cations le...

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Literature Corpus work: 709e4ccf-dc44-50a8-ae46-cc0d888da7d5
DOI: 10.1101/423442

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