Article
Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research.
Neural plasticity - 1 Jan 2012
Zachariah Robby Mathew, Rastegar Mojgan
Abstract excerpt
Epigenetics refer to inheritable changes beyond DNA sequence that control cell identity and morphology. Epigenetics play key roles in development and cell fate commitments and highly impact the etiology of many human diseases. A well-known link between epigenetics and human disease is the X-linked MECP2 gene, mutations in which lead to the neurological disorder, Rett Syndrome. Despite the fact that MeCP2 was...
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